刘晓,博士,副研究员,硕士生导师
联系方式:010-6428 6100; fcliuxiao@163.com; fcliuxiao@gmail.com.
个人简历
1987年11月出生于山东省泰安市
2004年09月-2008年07月:北京科技大学,生物技术专业,学士
2008年09月-2013年07月:中国医学科学院 北京协和医学院药物研究所,硕博连读
2013年07月 - 2017年12月:北京中医药大学中药现代研究中心,助理研究员
2018年01月-至今:北京中医药大学中药现代研究中心,副研究员
2019年09月赴美国德克萨斯大学奥斯汀分校University of Texas at Austin进行公派访学
研究领域
1. 微量/活性天然产物生物合成途径解析
2. 具新颖催化活性次级代谢酶的发现及机制研究
奖励荣誉
2019年8月起任中华中医药学会中药化学分会青年委员;
入选2018年度中国科协青年人才托举项目;
入选北京中医药大学杰出青年人才(优青培育)项目;
教育部高等学校科学研究优秀成果奖自然科学奖二等奖,2015年,第九完成人;
中国药学大会暨第十二届中国药师周优秀论文三等奖
代表论著 (限10篇)
1. Ridao Chen#, Bingquan Gao#, Xiao Liu#, Feiying Ruan, Yong Zhang, Jizhong Lou, Keping Feng, Carsten Wunsch, Shu-Ming Li, Jungui Dai*, Fei Sun*. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nature Chemical Biology . 2017, 13(2): 226–234. (Co-first author)
2. Xiao Liu, Dan Xie, Ridao Chen, Mei Mei, Jianhua Zou, Xiaoguang Chen, Jungui Dai*. A furantaxane with an unusual 6/8/6/5 ring system and potent tumor MDR reversal activity obtained via microbial transformation. Organic Letters , 2012, 14(16): 4106–4109.
4. Yuyu Liu, Xiaohui Wang, Ting Mo, Yaru Yan, Yuelin Song, Yunfang Zhao, Jun Li, Shepo Shi, Xiao Liu*, Pengfei Tu*. Identification and functional application of a new malonyltransferase NbMaT1 towards diverse aromatic glycosides from Nicotiana benthamiana . RSC Advances , 2017, 7: 21028–21035. (Co-corresponding author)
5. Xiao Liu, Ridao Chen, Dan Xie, Mei Mei, Jianhua Zou, Xiaoguang Chen, Jungui Dai*. Microbial transformations of taxadienes and the multi-drug resistant tumor reversal activities of the metabolites. Tetrahedron , 2012, 68(47): 9539–9549.
6. Bowen Qi#, Xiao Liu#, Ting Mo, Zhixiang Zhu, Jun Li, Juan Wang, Xiaoping Shi, Kewu Zeng, Xiaohui Wang, Pengfei Tu, Ikuro Abe, Shepo Shi*. Nitric oxide inhibitory polyketides from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrate . Fitoterapia , 2017, 123: 35–43. (Co-first author)
7. Xiao Liu*, Yaru Yan, Yuyu Liu, Ting Mo, Xiaohui Wang, Yuelin Song, Qingliang Chen, Yunfang Zhao, Shepo Shi*, Pengfei Tu*. Cell culture establishment and regulation of two phenylethanoid glycosides accumulation in cell suspension culture of desert plant Cistanche tubulosa . Plant Cell, Tissue and Organ Culture , 2018, 134(1), 107–118.
8. Yaru Yan, Bowen Qi, Ting Mo, Xiaohui Wang, Juan Wang, Shepo Shi*, Xiao Liu*, Pengfei Tu*. Research Progress of Rhamnosyltransferase. Chinese Journal of Organic Chemistry, 2018, 38, 2281–2295. (Co-corresponding author)
9. Ridao Chen, Xiao Liu; Jianhua Zou; Yunze Yin, Bin Ou, Jianhua Li, Ruishan Wang, Dan Xie, Peicheng Zhang, JunguiDai*. Regio- and stereospecific prenylation of flavonoids by Sophora flavescens prenyltransferase. Advanced Synthesis & Catalysis , 2013, 355(9): 1817–1828.
10. Bowen Qi, Xiao Liu, Ting Mo, Zhixiang Zhu, Jun Li, Juan Wang, Xiaoping Shi, Kewu Zeng, Xiaohui Wang, Pengfei Tu, Ikuro Abe, Shepo Shi*. 3,5-Dimethylorsellinic acid derived meroterpenoids from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrate . Journal of Natural Products , 2017, 80(10): 2699–2707.
科研项目
1. 2018年度中国科协青年人才托举项目,45万,2018.1-2020.12;主持
2. 北京市自然科学基金面上项目,20万,2019.1-2021.12;主持
3. 北京中医药大学杰出青年人才培育项目,20万,2018.1-2019.12;主持
4. 国家自然科学基金青年科学基金,24万,2015.1-2017.12;主持
5. 北京中医药大学自主选题项目,3万,2014.1-2014.12;主持