王金铃,博士,副研究员
联系方式:010-6428 6180;wangjinling22@163.com
个人简历
1985年9月出生于辽宁省辽阳市
2004年09月-2008年07月:沈阳药科大学,学士
2008年09月-2012年06月:沈阳药科大学,博士(直博生)
2012年7月至今:北京中医药大学中药现代研究中心,副研究员
研究领域
1. 中药新型给药系统的研究
2. 生物药剂学与药物动力学研究
代表论著(限10篇)
1. Wenzhuan Ma, Qiang Guo, Ying Li, Xiaohui Wang, Jinling Wang*, Pengfei Tu*. Co-assembly of doxorubicin and curcumin targeted micelles for synergistic delivery and improving anti-tumor efficacy. Eur J Pharm Biopharm, 2017, 112: 209-223.
2. Jinling Wang, Wenzhuan Ma, Qiang Guo, Ying Li, Zhogndong Hu, Pengfei Tu*. The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin. Int J Nanomedicine, 2016,11: 5851-5870.
3. Jinling Wang, Ying Li, Wenzhuan Ma, Xiaohui Wang, Pengfei Tu*. Validated LC-MS/MS method for simultaneous determination of doxorubicin and curcumin in polymeric micelles in subcellular compartments of MCF-7/Adr cells by protein precipitation- ultrasonic breaking method. [J]. Biomed Chromatogr, 2016, 3892.
4. Wang J, Ma W, Tu P*. The mechanism of self-assembled mixed micelles in improving curcumin oral absorption: in vitro and in vivo. Colloids and Surfaces B: Biointerfaces. 2015, 133: 108-119.
5. Wang J, Ma W, Tu P*. Synergistically Improved Anti-tumor Efficacy by Co-delivery Doxorubicin and Curcumin Polymeric Micelles. Macromol Biosci, 2015,15(9):1252-61. (IF="3.65)
6. Jinling Wang#, Lin Li#, Yuqian Du, Jin Sun, Zhonggui He, et al. Improved oral absorption of Doxorubicin by amphiphilic copolymer of lysine-linked ditocopherol polyethylene glycol 2000 succinate: in vitro characterization and in vivo evaluation. Mol Pharm, 2015,12(2):463-73.(#co-first)
7. Ma W#, Wang J#, Guo Q, Tu P*. Simultaneous determination of doxorubicin and curcumin in rat plasma by LC-MS/MS and its application to pharmacokinetic study. J Pharm Biomed Anal. 2015, 111:215-221.(#co-first)
8. Ma W#, Wang J#, Guo Q, Tu P*. Quantitative subcellular study of doxorubicin in MCF-7/Adr cellsusing liquid chromatography–tandem mass spectrometry. Journal of Chromatography B, 2015,1007:18–22. (#co-first)
9. 马文转, 王金铃*, 屠鹏飞*. 黄芩苷纳米胶束的制备、表征及其对MCF-7 细胞抑制作用的研究. 中草药, 2015, 46(4):507-512. (共同通讯作者)
10. 马文转, 王金铃*, 屠鹏飞*.盐酸小檗碱纳米胶束的制备、表征及体外抗肿瘤活性的研究. 中国中药杂志, 2015, 40(21):4182-4188. (共同通讯作者)
科研项目
1. 以穿心莲药效组分为模型药物的“三位一体”智能化胶束-微粒系统的构建及促口服吸收机制研究,国家自然科学基金青年科学基金项目(81503262),主持,2016.01-2018.12
2. 多功能纳米胶束用于中药姜黄素和化药联合增效减毒的研究,博士点新教师类项目(20130013120008),主持,2014.01-2016.12
3. 基于药代动力学复方丹参方中佐使冰片的择选研究,北京中医药大学“青年教师专项计划项目”(2013-QNJSZX024),主持,2014.01–2014.12