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在职教师

胡仲冬

  

  胡仲冬,博士

  助理研究员

  联系方式:010-6428 6180;huzhongdong@126.com

  

  个人简历

  1985年12月出生于湖南省衡阳市

  2004年09月—2008年07月:南开大学,学士

  2008年09月—2013年07月:北京协和医学院-清华大学医学部,博士(直博)

  2013年07月至今:北京中医药大学中药学院中药现代研究中心,助理研究员

  

  研究领域

  1. 中药活性成分抗肿瘤机制研究

  2. 肿瘤信号通路调控及靶向治疗研究

  

  代表论著(限10篇)

  1. Fuquan Jin, Keguo Jiang, Shuang Ji, Li Wang, Zhaofei Ni, Fuqiang Huang, Chunjia Li, Rongrong Chen, Hongbing Zhang, Zhongdong Hu*, and Xiaojun Zha. Deficient TSC1/TSC2-complex Suppression of SOX9-Osteopontin-AKT Signaling Cascade Constrains Tumor Growth in Tuberous Sclerosis Complex. Human Molecular Genetics . 2016 Dec 23. pii: ddw397. doi: 10.1093/hmg/ddw397. IF="5.985

  2. Zhongdong Hu, Ailin Yang, Guozhu Su, Yunfang Zhao, Ying Wang, Xingyun Chai, and Pengfei Tu. Huaier restrains proliferative and invasive potential of human hepatoma SKHEP-1 cells partially through decreased Lamin B1 and elevated NOV. Scientific Reports . 6, 31298; doi: 10.1038/srep31298 (2016). IF="5.228

  3. Zhongdong Hu, Ailin Yang, Haitao Fan, Ying Wang, Yunfang Zhao, Xiaojun Zha, Hongbing Zhang, Pengfei Tu. Huaier aqueous extract sensitizes cells to rapamycin and cisplatin through activating mTOR signaling. Journal of Ethnopharmacology .186 (2016) 143-150. IF="3.055

  4. Ailin Yang, Haitao Fan, Yunfang Zhao, Xiaojun Zha, Hongbing Zhang, Zhongdong Hu*, and Pengfei Tu. Huaier aqueous extract inhibits proliferation and metastasis of tuberous sclerosis complex cell models through downregulation of JAK2/STAT3 and MAPK signaling pathways. Oncology Reports 2016. 36(3):1491-1498. IF="2.486

  5. Xuelong Yu, Qiang Guo, Guozhu Su, Ailin Yang, Zhongdong Hu*, Changhai Qu, Zhe Wan, Ruoyu Li, Pengfei Tu, and Xingyun Chai. Usnic Acid Derivatives with Cytotoxic and Antifungal Activities from the Lichen Usnea longissimi. Journal of Natural Products . 2016, 79, 1373−1380. IF="3.662

  6. Hongwu Li, Fuquan Jin, Keguo Jiang, Shuang Ji, Li Wang, Zhaofei Ni, Xianguo Chen, Zhongdong Hu, Hongbing Zhang, Yehai Liu, Yide Qin, Xiaojun Zha. mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency. Oncotarget , 2016, 7(19): 28435-28447. IF="5.008

  7. Zhongdong Hu, Ying Wang, Fuqiang Huang, Rongrong Chen, Chunjia Li, Fang Wang, June Goto, David J. Kwiatkowski, Joanna Wdzieczak-Bakala, Pengfei Tu, Jianmiao Liu, Xiaojun Zha and Hongbing Zhang. Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis. Journal of Biological Chemistry 2015, 290(42):25756-65. IF="4.258

  8. Xiaojun Zha, Zhongdong Hu, Shuang Ji, Fuquan Jin, Keguo Jiang, Chunjia Li, Pan Zhao, Zhenzhen Tu, Xianguo Chen, Lijun Di, Haisheng Zhou, Hongbing Zhang. NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth. Cancer Letters 359 (2015) 97-106. (IF="5.992," co-first author)

  9. Ying Wang, Zhongdong Hu, Zhibo Liu, Rongrong Chen, Haiyong Peng, Xinxin Chen, Hongbing Zhang. mTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Autophagy 2013, 9(12): 2069-2086. IF="9.108

  10. Xiaojun Zha, Zhongdong Hu, Shaozong He, Fang Wang, Huangxuan Shen, Hongbing Zhang. TSC1/TSC2 inactivation inhibits AKT through mTORC1-dependent up-regulation of STAT3-PTEN cascade. Cancer Letters 313(2011) 211–217. (IF="5.992," co-first author)

  

  主持科研项目

  1.  槐耳均一多糖蛋白抗肿瘤活性及其作用机制研究,国家自然科学基金青年科学基金项目(81403147,主持),2015.01-2017.12

  2.  槐耳清膏对结节性硬化症的治疗作用及其机制研究,北京中医药大学杰出青年人才项目(2015-JYB-XYQ-004,主持),2015.07(连续资助)

作者:中药现代研究中心    发布日期:2014-03-19